Is aging a chronic disease?
Does this process have one reason?
If so, is there a common remedy?
Adult stem cells repair damaged and diseased tissues and continually replace worn-out normal tissue. However, a chronic decline in self-healing occurs with the age, starting from the time when we are still pretty young. In other words, aging is the result of a steady progressive decline in stem cell function, resulting in the need for antiaging stem cells.
If we take a closer look at aging, we see certain trends that led to Dr. Ron Dipigno of Harvard University proposing a unified theory of aging. He believes that damage to telomeres is the main cause of aging.
Telomeres can simply be described as tails attached to cells that represent their DNA.
Short telomeres ultimately act on mitochondria, causing them to become ineffective and inducing a "cell death spiral." Mitochondria produce free radicals that damage the body at many different levels. Think of them as terrorists in the body that do damage on multiple levels. A cell is programmed so that when its telomeres reach a certain critical level, the P-53 gene becomes active and leads to cell death. If the P-53 gene doesn't eliminate the aged cell, a lot of bad things begin. Simply put, if we could stop telomere shortening, we could not only lengthen our life but also live healthier in the process.
The idea that we are "dying of old age" is a common and misleading myth in modern medicine. We do not die of old age, but of cumulative failures in our cellular machines. These failures should not be viewed as inevitable failures, but as reversible elements of aging. This is the main message of our AntiAge program, in which we use a number of elements to counteract and possibly turn the clock back on aging.
The sirtuin gene pathway
Sirtuin genes are generally considered to be one of the most important anti-aging pathways as they have a powerful effect on mitochondria and their health. Mitochondria produce ATP, which is the fuel on which most cell functions rely. The healthier and more numerous the mitochondria, the healthier we are.
With age, the number and function of mitochondria decreases. The sirtuin genes are influenced by many factors. One of the factors that turns them on is hunger or calorie restriction. Fasting has been scientifically proven to slow down aging. There has been a lot of interest in the ketogenic diet lately, which appears to mimic many of the same effects of calorie restriction. Basically, it is a very low-carb diet that forces the body to use ketone bodies as an energy source. Ketone bodies have broad effects on a number of aging pathways, including the Sirtuin gene path.
Another factor that influences Sirtuin genes is resveratrol, which is obtained from red wine. The best alternative to resveratrol may be pterostilbene. Pterostilbene has better bioavailability than resveratrol. Numerous studies have shown that resveratrol and pterostilbene have a preventive and therapeutic effect on mitochondria.
The NAD pathway
In early 2018, Time magazine published an article highlighting the importance of NAD as a source and method of fighting aging. Here is an excerpt.
“NAD + is our closest fountain of youth,” says David Sinclair, co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. “This is one of the most important molecules for life, and without them, you will die in 30 seconds. All the good food you eat will do nothing for you if your cells cannot extract energy from it.
NAD + collects electrons, converts to NADH, and dumps them as part of a cycle that converts your food into energy that you use to move and think. At the cellular level, your mitochondria, your cells' batteries, use this energy to do what they need to do in order to survive and repair themselves in the case of damage or stress.
Several techniques can be used to increase the NAD available to cells. Some of these methods include NAD supplementation and the keto diet.
P-53 gene activation pathway
The P-53 gene is a protein known as a transcription factor. Transcription factors regulate genes by turning them on and off. The main function of the P-53 gene is to suppress the so-called senescent cells and their death. An aging cell is a cell that should have died but continues to survive. Cellular aging is a condition in which cells can no longer divide but continue to live and at the same time release growth factors that can cause serious diseases, including cancer, diabetes, and other diseases of aging. This explains why it is known in some circles as a tumor suppressor gene.
The method for assisting the P-53 gene is through the use of senolytic agents in the body. These are compounds that kill senescent cells, cells that should have died but instead stay alive and secrete many inflammatory growth factors.
The AMPK pathway
The AMPK path is situated in each system because of your body's “adjustable switch”. The most compelling evidence that AMPK activation can help you live longer comes from a study published in 2014. In this study, diabetic patients who used the drug metformin, a potent AMPK activator, lived on average 15% longer than their corresponding non-diabetic control groups.
When enabled, AMPK triggers the use of energy stored in the blood, increases mitochondrial consumption and reduces inflammation. Calorie restriction and vigorous exercise activate AMPK, reducing body fat stores (especially in the belly area), lowering blood sugar and lipids, and producing other beneficial effects that slow down the aging process. One way to maintain AMPK higher activity is to limit calories. To better understand how this works, in a low-calorie environment, survival signals (such as AMPK) are turned on to optimize your energy balance.
Chronic overeating deactivates AMPK and shortens life expectancy. We can restore our diminishing AMPK activity with new combinations of life, diet, and supplementation, significantly extending life expectancy by alleviating the fatal symptoms of aging.
The autophagy pathway
Autophagy is a process that works like our body's innate processing system. One of the characteristics of aging is the accumulation of damage to the extent that the autophagy fails to reach normal functional levels. In short, autophagy is critical to increasing life expectancy and preventing the diseases of aging.
The keto diet (high carb meal plan) is a good way to achieve autophagy. Intermittent fasting or calorie restriction for a short period has been shown to induce autophagy. When your cells lack nutrients, it causes stress on them. This is good because it increases the rate at which cells process components. A lack of nutrient supply activates autophagy to increase the recirculation of cellular components.
Intense interval training is another way to stimulate autophagy. You should aim for high-intensity exercise for 20-30 minutes a day to give your longevity a boost.
We gave an example of how the aging process occurs in the human body. At our center, we use nanotechnology to prevent aging, affecting all the links of aging, which will help delay the appearance of the first signs of aging and prolong youth.